Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s
نویسندگان
چکیده
منابع مشابه
Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
Recently, much attention has been given to the problem of drug delivery through the cell-membrane in order to treat and manage several diseases. The discovery of cell penetrating peptides (CPPs) represents a major breakthrough for the transport of large-cargo molecules that may be useful in clinical applications. CPPs are rich in basic amino acids such as arginine and lysine and are able to tra...
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Polymeric micelles that are composed of synthetic polymers are generally size controllable and can be easily modified for various applications. Lactosomes (A3B-type) are biodegradable polymeric micelles composed of an amphipathic polymer, including three poly(sarcosine) blocks and a poly(l-lactic acid) block. Lactosomes accumulate in tumors in vivo through the enhanced permeability and retentio...
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Cell-penetrating peptides (CPPs) mediate the uptake of interconnected cargoes of different types into cells and organisms. Studies in living cells revealed that high-molecular-weight cargoes linked to CPPs are delivered via endocytic routes whereas CPPs by themselves or fused to low-molecular-weight cargoes can in addition enter by a mechanism that does not require vesicle formation. This latte...
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The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore, mandatory. Since the seminal observations two decades ago that the Tat protein, and derived peptides, can translocate across biological membr...
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Over the past 20 years, cell-penetrating peptides (CPPs) have gained tremendous interest due to their ability to deliver a variety of therapeutically active molecules that would otherwise be unable to cross the cellular membrane due to their size or hydrophilicity. Recently, we reported on the identification of a novel CPP, sC18, which is derived from the C-terminus of the 18 kDa cationic antim...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2014
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja501581b